S
M
T
W
T
F
S
29
73°
42°
30
80°
59°
31
84°
65°
1
83°
64°
2
80°
67°
3
83°
67°
4
76°
45°
5
62°
37°
6
70°
34°
7
64°
44°
8
76°
45°
9
80°
55°
10
82°
56°
11
76°
56°
12
82°
59°
13
82°
70°
14
88°
65°
15
86°
67°
16
81°
58°
17
86°
57°
18
74°
43°
19
70°
36°
20
69°
44°
21
79°
51°
22
80°
52°
23
83°
50°
24
72°
58°
25
80°
55°
26
81°
52°
27
83°
65°
28
74°
57°
29
70°
45°
30
67°
47°
1
62°
42°
2
62°
39°
Temperature Graph
°F
Avg. Hi
Avg. Lo
Actual Hi
Actual Lo
Forecast Hi
Forecast Lo
April Weather in Cape Girardeau
Cape Girardeau's April 2026 forecast shows daily high temperatures ranging from 62° to 74°, with overnight lows between 39° and 57°. The average high for April is 67° with an average low of 46°. AccuWeather's monthly forecast extends further ahead than any other source, with day-by-day RealFeel® Temperatures giving a complete picture of how April weather will actually feel in Cape Girardeau. See also: May | June | July.