A major shift in the weather pattern will drive a blast of cool air southeastward from Canada across the Plains, Midwest, East and South into the weekend.
The blast of air from the Canada Prairies will drive temperatures and humidity levels down all the way to Texas and eventually much of the Atlantic Seaboard.
Temperatures may struggle to top 70 around Chicago both days of the weekend.
As the cooler air blasts across the warm waters of the Great Lakes, waterspouts are likely to spin up this weekend.
In Texas, the 100-degree heat from much of this summer will be replaced by highs in the 80s with much lower humidity in such cities as Dallas, San Angelo and Houston.
In the central and northern Appalachians, in the wake of the front which marks the leading edge of cooler air, the coolest spots could have highs near 60 on Sunday.
In the Deep South, for the folks who have been enduring tropical heat and humidity this week while cleaning up after Isaac, highs in the 80s with low humidity and sunshine will settle in later this weekend into next week.
While the magnitude of cooling will be less pronounced in much of the East's I-95 corridor, humidity levels will be shaved substantially and highs will be in the 70s by early next week from Boston to New York City and Washington, D.C.
The blast of cooler air and refreshing humidity will be preceded by rounds of showers and thunderstorms, which can lead to flash flooding and localized severe weather.
The downpours and severe weather will hit portions of the Midwest Friday then the Deep South and Atlantic coast into the weekend.
In addition, folks in portions of Florida may have to deal with a weak tropical system, such as a tropical depression or tropical storm and its torrential downpours this weekend. The feature could come about of a cluster of thunderstorms over the northern Gulf of Mexico, which are part of the old remains of Isaac.
As cooler air drives into the eastern U.S. this weekend, a compensating northerly flow over the Atlantic Ocean may help drive Hurricane Leslie into Atlantic Canada early next week.
Travel hazards, delays and disruptions associated with rain, ice and snow will continue over the Central states through the balance of the Thanksgiving weekend.
The current reprieve from heavy rain across southern India will not last long with the threat for flooding downpours set to return for the final days of November.
Sandra has weakened to a tropical storm but remains on track to make landfall in western Mexico with flooding rainfall on Saturday.
Heavy thunderstorms will continue to shift northward across central South America with the greatest threat for flooding focusing on northeastern Argentina and eastern Paraguay into Saturday morning.
Several days of heavy rain will bring the potential for significant flooding from the southern Plains to the middle Mississippi Valley into early next week.
Snow and ice storms have taken aim at the Central U.S. this week, while record-setting Sandra strengthened into a major hurricane south of Mexico.
Goodland, KS (1983)
19 inches of snow on the ground with drifts of up to 8 feet.
Sixty cities tied or established new record high temperatures for the date.
Chardon, OH (1996)
A bull's eye for lake effect snow for the month with more than 70".