There is the risk of strong to locally severe thunderstorms for a time Wednesday night from northern Louisiana to southern Illinois.
The greatest risks from the storms will be strong wind gusts and hail, as well as flash and urban flooding.
Cities that could be hit by the strong storms and their gusty winds and blinding downpours include Little Rock, Ark.; Memphis, Tenn.; Tupelo, Miss.; Monroe, La., Cape Girardeau, Mo.; Louisville, Ky.; and Evansville, Ind.
Even as the potential for severe thunderstorms decreases after midnight, showers and locally heavy, gusty thunderstorms will continue along an advancing front as it pushes to the east through Thursday.
There is a slight chance of a couple of the strongest storms producing a tornado.
A strong flow of air behind the front can bring damaging wind gusts even without thunderstorms.
There is the potential for nearly hurricane-force wind gusts in the clear air spanning thousands of square miles expanding from the northern Rockies to the northern and central Plains during the middle of the week.
Very blustery conditions are likely to sweep into the middle Mississippi and Ohio valleys Wednesday night and Thursday in the wake of the front.
Four people in Florida are likely the first in the United States to contract the Zika virus by local mosquitoes, officials said Friday.
Rounds of drenching showers and heavy thunderstorms will heighten the risk of flash flooding across the northeastern United States through the final weekend of July.
Rounds of showers and thunderstorms moving westward off the coast of Africa may pave the way for future tropical systems over the Atlantic Ocean in the weeks ahead.
The Formula One race in Hockenheim, Germany, this weekend could become the third consecutive race to be disrupted by showers and thunderstorms.
Additional downpours are likely to roll across northern New Jersey and could suspend play during the late rounds at the 98th PGA Championship at Baltusrol Golf Club this weekend.
Tropical Depression 06w threatens to bring flooding rain to the Philippines into this weekend with potential future impacts on China and Taiwan.
Albuquerque, NM (1997)
A propane truck blew up after being struck by lightning. 3 people were injured.
Pittsburgh, PA (1999)
Stroudsburg, PA (2009)
A tornado downed trees and destroyed four large farm buildings and a single family house. Two injuries were reported.