There is the risk of strong to locally severe thunderstorms for a time Wednesday night from northern Louisiana to southern Illinois.
The greatest risks from the storms will be strong wind gusts and hail, as well as flash and urban flooding.
Cities that could be hit by the strong storms and their gusty winds and blinding downpours include Little Rock, Ark.; Memphis, Tenn.; Tupelo, Miss.; Monroe, La., Cape Girardeau, Mo.; Louisville, Ky.; and Evansville, Ind.
Even as the potential for severe thunderstorms decreases after midnight, showers and locally heavy, gusty thunderstorms will continue along an advancing front as it pushes to the east through Thursday.
There is a slight chance of a couple of the strongest storms producing a tornado.
A strong flow of air behind the front can bring damaging wind gusts even without thunderstorms.
There is the potential for nearly hurricane-force wind gusts in the clear air spanning thousands of square miles expanding from the northern Rockies to the northern and central Plains during the middle of the week.
Very blustery conditions are likely to sweep into the middle Mississippi and Ohio valleys Wednesday night and Thursday in the wake of the front.
Tropical Storm Matthew has formed in the Caribbean could take a turn toward the United States as a hurricane next week.
It will feel like an extended winter for those living from the northern Plains to the eastern U.S., as cold and snowy conditions last longer than normal.
The final day of September will bring a rare lunar event that hasn’t occurred since March of 2014, a Black Moon.
Rain will spread over much of the northeastern U.S. into the weekend, but persistent downpours will raise the flood risk in part of the mid-Atlantic.
A new typhoon is brewing in the western Pacific Ocean and could pose a risk to Japan, Taiwan and eastern China next week.
Thundery showers set to start this weekend will depart before the season's first National Football League game in London kicks off on Sunday.
Cedar Keys, FL (1896)
Hurricane killed 110; $3.8 million damage.
Pensacola, FL (1917)
28.51 inches -- lowest pressure at Pensacola. Wind gusts to 95 mph.
Key Largo, FL (1929)
Hurricane with central pressure of 948.2 or 28.00 inches; winds up to 150 mph. Ten-minute average when eye passed over station; 3 killed; $800,000 damage.