1. The snow in the Midwest will be an unprecedented event for that area. I have never seen that much snow in early May across that area. In fact, some of the research done by Alex shows that many of the major cities had up to 2 inches of snow for early May as the most snow. While I think 3-6 inches of snow can fall, it's not out of the question due to the convection and pivoting of the precip, that some local areas get up to 10 inches of snow.
2. Heavy thunderstorms today in the area shown on the map. Storms in that area will produce large hail and damaging winds. The storms will morph into a heavy rain area which could result in flooding before that change to snow occurs.
3. The upper-level low will settle in the Midwest for a few days, and that will spin heavy rain across the Mississippi Valley. The heavy rains will only aggravate the flooding problems.
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The band of snow and ice that develops this weekend will be bad in Kansas but more of a nuisance through the Ohio Valley.
As milder weather moves north, it will mean snow will hit the Great Lakes and Northeast today into tonight. California will get more heavy rain.